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The research work of Dr Roberto Pinelli and his team in the field of ophthalmology is not limited to surgical techniques, but also includes eye therapies and treatments, and the study of molecules and compounds that have a fundamental role in certain areas of visual science.<\/p>\n
They include ParaCel\u00ae, an eyewash developed by Dr Pinelli to improve the penetration of riboflavin (vitamin B2) into the corneal stroma during corneal collagen cross-linking for the treatment of keratoconus.<\/p>\n
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Keratoconus, an eye disorder which presents as myopia associated with irregular astigmatism, is caused by the presence of one or more cone-like bulges on the cornea which affect visual acuity. As it is often a degenerative condition, in the past there was no alternative to corneal transplant in the treatment of the most severe cases. Today this can be avoided thanks to a procedure known as corneal cross-linking, which uses the synergic action of riboflavin (vitamin B2) and UV-A rays to create new collagen bonds, thus strengthening the cornea.<\/p>\n
Dr Pinelli has developed an important variation on this technique: accelerated trans-epithelial osmotic cross-linking, now a common practice among many eye surgeons all over the world. This procedure preserves the patient\u2019s corneal epithelium, the outer and thinner layer of the cornea, which is normally removed in traditional cross-linking operations.<\/p>\n
Dr Pinelli has always supported minimally invasive approaches and procedures in ophthalmology and the need to avoid pain whenever possible. This was the underlying principle in all his research, in any field, including cross-linking for keratoconus. It was this approach that led Dr Pinelli and his team to develop an eyewash that penetrates deeply into the cornea (its penetration capacity was tested by the laboratories of the State University of Milan and the University of Dresden) thus making the removal of the upper part of the cornea unnecessary and eliminating post-op pain.<\/p>\n
The international patent of this drug was purchased by Avedro, a well-known US-based multinational with a strong interest in ophthalmic research and innovation, which has marketed Dr Pinelli\u2019s eye drops worldwide under the brand name ParaCel \u00ae.<\/p>\n
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PARACEL\u00aeOSMOSIS IN ACTIONThe research work of Dr Roberto Pinelli and his team in the field of ophthalmology is not limited to surgical techniques, but also includes eye therapies and treatments, and the study of molecules and compounds that have a fundamental role in certain areas of visual science. They include ParaCel\u00ae, an eyewash developed by […]<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":5877,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"[mk_page_section bg_image=\"http:\/\/www.seri-lugano.ch\/wp-content\/uploads\/2018\/01\/paracelfascia.jpg\" sidebar=\"sidebar-1\"][vc_column][mk_padding_divider size=\"100\"][mk_padding_divider size=\"100\"][mk_padding_divider size=\"100\"][\/vc_column][\/mk_page_section][mk_page_section bg_color=\"#dd3333\" video_loop=\"false\" min_height=\"57\" full_width=\"true\" sidebar=\"sidebar-1\"][vc_column][vc_column_text]\n
La ricerca in ambito oftalmico del Dr. Roberto Pinelli e del suo team non riguarda solo le tecniche operatorie<\/b>, ma si rivolge anche a trattamenti terapeutici\u00a0<\/b>e allo studio di molecole\u00a0<\/b>e composti che giocano un ruolo importante in alcuni ambiti della scienza della visione.<\/b><\/p>\n
E\u2019 questo il caso di\u00a0<\/span>ParaCel\u00ae<\/b>, collirio ideato dal Dr. Pinelli per consentire la penetrazione della necessaria quantit\u00e0 di riboflavina (vitamina B2) nello stroma corneale nel corso di un\u00a0<\/span>cross-linking corneale<\/b>\u00a0<\/span>per il trattamento del\u00a0<\/span>cheratocono<\/b>.<\/p>\n Il cheratocono<\/b>\u00a0<\/span>\u00e8 una patologia della cornea che si presenta come una miopia associata ad astigmatismo irregolare <\/b>dovuta alla presenza di una o pi\u00f9 protuberanze sulla cornea<\/b>, detti appunto coni<\/b>, che ne alterano la capacit\u00e0 visiva. Ad andamento spesso ingravescente, il\u00a0<\/span>cheratocono <\/b>portava nei casi pi\u00f9 complessi inesorabilmente al trapianto di cornea<\/b>, oggi sventato grazie all\u2019avvento di una procedura detta\u00a0<\/span>cross-linking <\/b>corneale <\/b>che fortifica la cornea grazie alla creazione di nuovi legami di collagene\u00a0<\/b>ad opera dell\u2019azione sinergica di raggi UV-A\u00a0<\/b>e riboflavina, vitamina B2<\/b>.<\/p>\n Il Dr. Pinelli \u00e8 fautore di una tecnica personale, il\u00a0<\/span>cross-linking<\/b>\u00a0<\/span>osmotico transepiteliale<\/b>\u00a0<\/span>\u2013 oggi largamente diffusa nel mondo perch\u00e9 entrata a far parte dell\u2019attivit\u00e0 di altri chirurghi oculari \u2013 che mantiene intatto l\u2019epitelio corneale<\/b>, la parte pi\u00f9 esterna e sottile della cornea, che veniva eliminato nel trattamento tradizionale di\u00a0<\/span>cross-linking<\/b>.<\/p>\n Il Dr. Pinelli \u00e8 sempre stato convinto della validit\u00e0 in oftalmologia di approcci e procedure assolutamente non invasive\u00a0<\/b>e nella necessit\u00e0 di evitare anche il minimo dolore, soprattutto se assolutamente non giustificato. Con questi presupposti si \u00e8 mossa la ricerca del suo gruppo anche nella cura del\u00a0<\/span>cheratocono<\/b>\u00a0<\/span>tramite\u00a0<\/span>cross-linking<\/b>, puntando su un collirio\u00a0<\/b>la cui capacit\u00e0 di penetrazione, testata in laboratorio dall\u2019Universit\u00e0 Statale di\u00a0<\/b>Milano e dall\u2019Universit\u00e0 di Dresda<\/b>, consentisse di non rimuovere la parte superficiale della cornea, evitando l\u2019inutile dolore post-operatorio.<\/p>\n Il brevetto internazionale\u00a0<\/b>del farmaco \u00e8 stato acquisito dalla compagnia statunitense Avedro Inc.<\/b>, multinazionale famosa per la forte propensione alla ricerca e innovazione\u00a0<\/b>in campo oculistico, che l\u2019ha commercializzato in tutto il mondo con il nome di\u00a0<\/span>ParaCel\u00ae<\/b>.<\/p>\n